Model T muscle CARs can treat brain tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23019306.
- Also identified by DOI 10.1158/1078-0432.CCR-12-2627.
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Abstract
Despite standard treatment with resection, radiation, and chemotherapy, glioblastoma remains a deadly disease with a dismal prognosis. Redirecting patient T cells to target the glioblastoma-associated antigen, IL13Rα2, offers a promising translational immunotherapy with the potential to make a meaningful impact for patients with this disease.
Medical subject headings
- Glioblastoma
- Interleukin-13 Receptor alpha2 Subunit
- Receptors, Antigen, T-Cell
- T-Lymphocytes