A mouse model for HIV-1 entry.
basic_science · Level V
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- Record sourced from PubMed, PMID 23019371.
- Also identified by PMC identifier 3465400.
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Abstract
Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody's ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions.
Medical subject headings
- Antibodies, Neutralizing
- Antibodies, Viral
- Disease Models, Animal
- HIV Infections
- HIV-1
- Virus Internalization