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editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23021211.
- Also identified by DOI 10.1016/j.cell.2012.09.006.
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Abstract
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.