In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging.
basic_science · Level V
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- Record sourced from PubMed, PMID 23022876.
- Also identified by DOI 10.1016/j.actbio.2012.09.023.
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Abstract
An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches.
Medical subject headings
- Calcium Phosphates
- Doxorubicin
- Drug Delivery Systems
- Ferric Compounds
- Gelatin
- Magnetic Resonance Spectroscopy
- Surface-Active Agents