Construction of a 4 zeptoliters switchable 3D DNA box origami.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23030709.
- Also identified by DOI 10.1021/nn303767b.
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Abstract
The DNA origami technique is a recently developed self-assembly method that allows construction of 3D objects at the nanoscale for various applications. In the current study we report the production of a 18 × 18 × 24 nm(3) hollow DNA box origami structure with a switchable lid. The structure was efficiently produced and characterized by atomic force microscopy, transmission electron microscopy, and Förster resonance energy transfer spectroscopy. The DNA box has a unique reclosing mechanism, which enables it to repeatedly open and close in response to a unique set of DNA keys. This DNA device can potentially be used for a broad range of applications such as controlling the function of single molecules, controlled drug delivery, and molecular computing.
Medical subject headings
- Crystallization
- DNA
- Nanostructures