Protein encapsulation within synthetic molecular hosts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23033069.
- Also identified by DOI 10.1038/ncomms2093.
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Abstract
Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been a daunting challenge because of their incommensurably larger size compared with common synthetic hosts. Here we report the encapsulation of a small protein, ubiquitin, within giant coordination cages. The protein was attached to one bidentate ligand and, upon addition of Pd(II) ions (M) and additional ligands (L), M(12)L(24) coordination nanocages self-assembled around the protein. Because of the well-defined host framework, the protein-encapsulated structure could be analysed by NMR spectroscopy, ultracentrifugation and X-ray crystallography.
Medical subject headings
- Proteins