Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease.
case_control · Level III
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- Record sourced from PubMed, PMID 2303829.
- Also identified by PMC identifier 1014094.
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Abstract
Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.
Medical subject headings
- Alzheimer Disease
- Brain
- Neuropsychological Tests
- Tomography, X-Ray Computed