Fate through fat: lipid metabolism determines stem cell division outcome.
basic_science · Level V
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- Record sourced from PubMed, PMID 23040066.
- Also identified by DOI 10.1016/j.cmet.2012.09.011 and PMC identifier 4045100.
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Abstract
Distinctive metabolism associated with particular cell states is increasingly being defined in normal and malignant cells. Ito et al. (2012) now show that fatty acid oxidation is associated with hematopoietic stem cells and determines whether they undergo symmetric or asymmetric cell division, driving a fundamental property of the stem cell state.