Pluripotency network in embryonic stem cells: maybe Leibniz was right all along.
editorial · Level V
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- Record sourced from PubMed, PMID 23040470.
- Also identified by DOI 10.1016/j.stem.2012.09.005.
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Abstract
The transcription factors Tcf3 and Nanog regulate many genes in embryonic stem cells, but according to two reports in this issue of Cell Stem Cell (Festuccia et al., 2012, Martello et al., 2012), only one, Esrrb, encoding an orphan nuclear hormone receptor, truly matters in the maintenance of self-renewal.