Order from chaos: single cell reprogramming in two phases.
basic_science · Level V
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- Record sourced from PubMed, PMID 23040472.
- Also identified by DOI 10.1016/j.stem.2012.09.004.
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Abstract
The generation of induced pluripotent stem cells (iPSCs) is considered to be stochastic with a minute fraction of cells becoming pluripotent. Recently in Cell, Buganim et al. (2012) changed this view using single cell analyses to reveal a stochastic early and hierarchical late phase, with implications for productive alternative reprogramming strategies.