Differential contributions of conformation extension and domain unfolding to properties of fibronectin nanotextiles.
basic_science · Level V
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- Record sourced from PubMed, PMID 23043581.
- Also identified by DOI 10.1021/nl302643g.
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Abstract
Fibronectin (FN) textiles are built as nanometer-thick fabrics. When uniaxially loaded, these fabrics exhibit a distinct threshold between elastic and plastic deformation with increasing stretch. Fabric mechanics are modeled using an eight-chain network and two-state model, revealing that elastic properties of FN depend on conformational extension of the protein and that plastic deformation depends on domain unfolding. Our results suggest how the molecular architecture of a molecule can be exploited for designer mechanical properties of a bulk material.
Medical subject headings
- Fibronectins