Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23055399.
- Also identified by DOI 10.1002/adma.201202932 and PMC identifier 3918481.
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Abstract
DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.
Medical subject headings
- DNA
- Nanoparticles
- Plasmids
- Polymers