Azumolene reverses episodes of malignant hyperthermia in susceptible swine.
basic_science · Level V
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- Record sourced from PubMed, PMID 2305975.
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Abstract
Azumolene is an analogue of dantrolene with much greater water solubility. Ten swine susceptible to malignant hyperthermia (MH) were triggered into MH episodes via the inhalation of halothane, and azumolene was effective in terminating all of the MH episodes. There was an inverse relationship between the dose of azumolene required to terminate the MH episode and the time it took for the pig to manifest the signs of MH. Azumolene was found to be similar in potency to dantrolene.
Medical subject headings
- Imidazoles
- Malignant Hyperthermia
- Muscle Relaxants, Central
- Oxazoles