A sensitive H2O2 assay based on dumbbell-like PtPd-Fe3O4 nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23060096.
- Also identified by DOI 10.1002/adma.201203218.
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Abstract
Dumbbell-like Pt(48)Pd(52)-Fe(3)O(4) nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H(2)O(2) reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt(48)Pd(52)-Fe(3)O(4)/TMB kit is even more active than the natural enzyme for H(2)O(2) detection with a detection limit reaching 2 μM, and is successfully used to quantitatively monitor the extracellular H(2)O(2) generated by neutrophils.
Medical subject headings
- Hydrogen Peroxide
- Magnetite Nanoparticles
- Palladium
- Platinum