Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23063018.
- Also identified by DOI 10.1016/j.ajog.2012.09.021.
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Abstract
Plasma concentrations of 17-alpha-hydroxyprogesterone caproate (17-OHPC) vary substantially in pregnant patients who receive an identical dose. Endogenous steroid hormones may alter 17-OHPC metabolism, which contributes to this large variability. Pooled human liver microsomes were incubated with 17-OHPC alone or in combination with progesterone, hydroxyprogesterone, estrone, estradiol, or estriol. High-performance liquid chromatography with ultraviolet detection was used to quantify 17-OHPC. Under the conditions that were studied, 17-OHPC metabolism was inhibited by 37% by a combination of endogenous steroid hormones. Progesterone alone significantly inhibited 17-OHPC metabolism by 28% (P < .001). 17-OHPC metabolism is inhibited significantly by endogenous steroids and, in particular, progesterone. This effect may account for some of the large variation in plasma 17-OHPC concentrations that is seen in pregnant patients who receive a fixed dose of medication.
Medical subject headings
- Estrogens
- Hydroxyprogesterones
- Microsomes, Liver
- Progesterone