A helicase with an extra spring in its step.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23063116.
- Also identified by DOI 10.1016/j.cell.2012.09.031.
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Abstract
DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.