The problem with mixing mitochondria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23063117.
- Also identified by DOI 10.1016/j.cell.2012.09.028.
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Abstract
Mixing of mitochondrial DNAs (heteroplasmy) is unfavorable for reasons unknown. Sharpley et al. show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes.