A circuit mechanism for neurodegeneration.
basic_science · Level V
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- Record sourced from PubMed, PMID 23063119.
- Also identified by DOI 10.1016/j.cell.2012.09.030.
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Abstract
How deficiency in SMN1 selectively affects motoneurons in spinal muscular atrophy is poorly understood. Here, Imlach et al. and Lotti et al. show that aberrant splicing of Stasimon in cholinergic sensory neurons and interneurons leads to motoneuron degeneration, suggesting that altered circuit function may underlie the disorder.