Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.
basic_science · Level V
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- Record sourced from PubMed, PMID 23071300.
- Also identified by DOI 10.1073/pnas.1215241109 and PMC identifier 3497735.
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Abstract
The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.
Medical subject headings
- RNA Polymerase II