Sisyphus and translational stroke research.
Where this comes from
- Record sourced from PubMed, PMID 23076354.
- Also identified by DOI 10.1126/scitranslmed.3005083.
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Abstract
After more than 1000 failures, we know that our methods for translating effective stroke treatments from the laboratory to the clinic do not work. New preclinical and clinical approaches conceived outside of the current paradigm exist and should be carefully considered. Now, Tymianski and colleagues report on results obtained during translation of a new neuroprotectant.
Medical subject headings
- Animals
- Biological Assay
- Brain Ischemia
- Brain Ischemia/therapy
- Chemistry, Pharmaceutical
- Chemistry, Pharmaceutical/methods
- Drug Design
- Drug Evaluation, Preclinical
- Drug Evaluation, Preclinical/methods
- Humans
- Neuroprotective Agents
- Neuroprotective Agents/therapeutic use
- Stroke
- Stroke/therapy
- Translational Research, Biomedical
- Translational Research, Biomedical/methods
- Treatment Outcome