Use of oral fluid to examine the molecular epidemiology of varicella zoster virus in the United Kingdom and continental Europe.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23087434.
- Also identified by DOI 10.1093/infdis/jis649 and PMC identifier 3549596.
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Abstract
We investigated oral fluid (OF) as an alternative to sampling of rashes for varicella zoster virus (VZV) genotyping and further characterized VZV clade prevalence in the United Kingdom and Europe. VZV was detected in up to 91% of OF specimens. Paired OF and vesicle fluid samples contained identical VZV clades. While clades 1 and 3 were the most prevalent across the United Kingdom and Europe, in Western Europe, clade 5 viruses were circulating. Viruses from the same outbreak belonged to different clades, but no clade was associated with a severe-disease phenotype. OF is suitable and convenient for large-scale molecular epidemiological studies of VZV.
Medical subject headings
- Chickenpox
- Herpes Zoster
- Herpesvirus 3, Human
- Molecular Epidemiology
- Polymorphism, Single Nucleotide
- Saliva