Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 2308963.
- Also identified by PMC identifier 53619.
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Abstract
Neuronally differentiated PC12 cells secrete decreasing amounts of [3H]norepinephrine when repetitively stimulated by depolarizing concentrations of potassium ion. The decreasing response shows attributes that have been classically ascribed to response habituation, a behavior commonly observed in nervous systems but found here in a homogeneous cell type. Alteration of the habituation pattern was caused by activators of the protein kinase C pathway and of voltage-gated calcium channels.
Medical subject headings
- Norepinephrine
- Tumor Cells, Cultured