Genetic "lnc"-age of noncoding RNAs to human disease.
editorial · Level V
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- Record sourced from PubMed, PMID 23093789.
- Also identified by DOI 10.1172/JCI66645 and PMC identifier 3484469.
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Abstract
The list of functions of long noncoding RNAs (lncRNAs) in human tissues is rapidly growing. To further underscore their critical role in human health, two reports in this issue of JCI associate altered expression of novel lncRNAs with the heritable syndromes HELLP and brachydactyly type E.
Medical subject headings
- Brachydactyly
- Cell Cycle
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 17
- Gene Expression Regulation
- Genetic Diseases, Inborn
- Genetic Loci
- HELLP Syndrome
- RNA, Long Noncoding
- Translocation, Genetic
- Trophoblasts