A missing link in genotype-directed cancer therapy.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23101617.
- Also identified by DOI 10.1016/j.cell.2012.10.014.
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Abstract
Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.
Medical subject headings
- Antineoplastic Agents
- Neoplasms
- Precision Medicine
- Signal Transduction