Revisiting global gene expression analysis.
review · Level V
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- Record sourced from PubMed, PMID 23101621.
- Also identified by DOI 10.1016/j.cell.2012.10.012 and PMC identifier 3505597.
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Abstract
Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states in disease, and for many other purposes. Recent studies indicate that common assumptions currently embedded in experimental and analytical practices can lead to misinterpretation of global gene expression data. We discuss these assumptions and describe solutions that should minimize erroneous interpretation of gene expression data from multiple analysis platforms.
Medical subject headings
- Gene Expression Profiling