Introducing Drugster: a comprehensive and fully integrated drug design, lead and structure optimization toolkit.

Vlachakis, Dimitrios; Tsagrasoulis, Dimosthenis; Megalooikonomou, Vasileios; Kossida, Sophia · Bioinformatics · 2013

basic_science · Level V

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Abstract

Drugster is a fully interactive pipeline designed to break the command line barrier and introduce a new user-friendly environment to perform drug design, lead and structure optimization experiments through an efficient combination of the PDB2PQR, Ligbuilder, Gromacs and Dock suites. Our platform features a novel workflow that guides the user through each logical step of the iterative 3D structural optimization setup and drug design process, by providing a seamless interface to all incorporated packages. Drugster can be freely downloaded via our dedicated server system at http://www.bioacademy.gr/bioinformatics/drugster/.

Medical subject headings