Immunosuppression increases JC polyomavirus large T antigen DNA load in the brains of patients without progressive multifocal leukoencephalopathy.
case_control · Level III
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- Record sourced from PubMed, PMID 23112281.
- Also identified by DOI 10.1093/infdis/jis668.
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Abstract
The relationship between latent JC polyomavirus (JCV) infection and progressive multifocal leukoencephalopathy (PML) remains unclear. In this study, JCV DNA was quantified by real-time polymerase chain reaction (qPCR) in brain and kidney tissue from patients without PML. Immunosuppressed patients had significantly higher JCV DNA levels in brain, compared with immunocompetent patients (P = .001). An inverse relationship was observed between CD4(+) T-cell counts and qPCR-determined brain JCV load among patients with HIV infection (r(2) = -0.9; P = .01; n = 7). Higher kidney JCV DNA load was strongly associated with higher brain JCV DNA load (Spearman ρ = 0.65; P = .004; n = 18). These findings highlight the importance of latent JVC brain infection to the pathogenesis of PML.
Medical subject headings
- Antigens, Polyomavirus Transforming
- HIV Infections
- JC Virus
- Leukoencephalopathy, Progressive Multifocal
- Polyomavirus Infections
- Tumor Virus Infections