Stressed out: endogenous aldehydes damage hematopoietic stem cells.
review · Level V
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- Record sourced from PubMed, PMID 23122283.
- Also identified by DOI 10.1016/j.stem.2012.10.007.
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Abstract
Despite a well-defined role for the Fanconi anemia (FA) pathway in mediating DNA repair, the mechanisms underlying the bone marrow failure in FA patients are poorly defined. Recently in Nature, Garaycoechea et al. (2012), identify aldehyde-mediated genotoxicity of hematopoietic stem cells as a cause for bone marrow failure.