A defect in vasopressin secretion in autosomal dominant polycystic kidney disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23128116.
- Also identified by DOI 10.1038/ki.2012.271.
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Abstract
A nephrogenic defect in urine concentration is well established in patients with polycystic kidney disease, but Ho et al. report a defect in the increase of plasma vasopressin in response to dehydration. On a cellular level, transient receptor potential channels responsible for osmoperception could interact with TRPPs encoded by the polycystic genes PKD1 and PKD2.
Medical subject headings
- Hypothalamus
- Kidney
- Osmoregulation
- Polycystic Kidney, Autosomal Dominant