Nanoparticle-induced permeability of lipid membranes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23128273.
- Also identified by DOI 10.1021/nn3028858.
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Abstract
Monte Carlo simulations using the bond fluctuation method with explicit solvent reveal the mechanism of enhanced permeability of lipid bilayers induced by the adsorption of nanoparticles with controlled hydrophobicity. Simulation results indicate an adsorption transition of nanoparticles on the bilayer in a certain range of relative degree of hydrophobicity. In this range the nanoparticles can translocate through the bilayer, reversibly destabilizing the structure of the bilayer and inducing enhanced permeability for water and small solutes. This transition is broader for amphiphilic nanoparticles.
Medical subject headings
- Cell Membrane Permeability
- Lipid Bilayers
- Nanoparticles