DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data.
other · Level V
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- Record sourced from PubMed, PMID 23129297.
- Also identified by DOI 10.1093/bioinformatics/bts656 and PMC identifier 3530913.
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Abstract
Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories. Negatively correlated profiles can be used to generate hypotheses of drug-repurposing, whereas positively correlated profiles may be used to infer side effects of drugs. DvD allows users to compare drug and disease signatures with dynamic access to databases Array Express, Gene Expression Omnibus and data from the Connectivity Map. R package (submitted to Bioconductor) under GPL 3 and Cytoscape plug-in freely available for download at www.ebi.ac.uk/saezrodriguez/DVD/.
Medical subject headings
- Drug Repositioning
- Software
- Transcriptome