Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.
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- Record sourced from PubMed, PMID 23132949.
- Also identified by DOI 10.1073/pnas.1206376109 and PMC identifier 3511102.
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Abstract
Nonribosomal peptides are highly sought after for their therapeutic applications. As with other natural products, dereplication of known compounds and focused discovery of new agents within this class are central concerns of modern natural product-based drug discovery. Development of a chemoinformatic library-based and informatic search strategy for natural products (iSNAP) has been constructed and applied to nonribosomal peptides and proved useful for true nontargeted dereplication across a spectrum of nonribosomal peptides and within natural product extracts.
Medical subject headings
- Algorithms
- Biological Products
- Computational Biology
- Peptides