SAMHD1 does it again, now in resting T cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23135508.
- Also identified by DOI 10.1038/nm.2980 and PMC identifier 4036678.
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Abstract
A long-standing question in the HIV field is why HIV-1 fails to replicate in resting CD4(+) T cells. A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile α motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).
Medical subject headings
- CD4-Positive T-Lymphocytes
- HIV-1
- Monomeric GTP-Binding Proteins