Waking up HSCs: a new role for E-selectin.
editorial · Level V
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- Record sourced from PubMed, PMID 23135509.
- Also identified by DOI 10.1038/nm.2992.
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Abstract
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained unclear. A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651-1657).
Medical subject headings
- Bone Marrow Cells
- Cell Proliferation
- E-Selectin
- Hematopoietic Stem Cells
- Neutrophils