Protective immunity from a germinal center sanctuary.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23135510.
- Also identified by DOI 10.1038/nm.2986.
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Abstract
A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673-1681).
Medical subject headings
- CD8-Positive T-Lymphocytes
- SAIDS Vaccines
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Vaccines, Attenuated