A sirtuin link between metabolism and heart disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23135512.
- Also identified by DOI 10.1038/nm.2983 and PMC identifier 3638005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643-1650).
Medical subject headings
- Cardiomegaly
- Heart Failure
- JNK Mitogen-Activated Protein Kinases
- Oncogene Protein v-akt
- Sirtuins