Protein-size molecularly imprinted polymer nanogels as synthetic antibodies, by localized polymerization with multi-initiators.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23135892.
- Also identified by DOI 10.1002/adma.201203400.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A new approach is proposed for the synthesis of molecularly imprinted polymers (MIPs) (synthetic antibodies) as soluble nanogels with sizes close to the size of real antibodies. To imprint a molecular memory in particles consisting of only a few polymer chains, an initiator carrying multiple iniferter moieties is used. This allows for the simultaneous initiation of several polymer chains, and yields molecularly imprinted nanogels (17 nm, molecular weight (MW) = 97 kDa) with good affinity and selectivity for the target.
Medical subject headings
- Antibodies
- Biomimetic Materials
- Molecular Imprinting
- Polyethylene Glycols
- Polyethyleneimine
- Polymers