Ketotifen prevents skin fibrosis in the tight skin mouse.
basic_science · Level V
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- Record sourced from PubMed, PMID 2313674.
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Abstract
Mast cells in the skin of the tight-skin mouse show an enhanced degranulation compared to those of syngeneic litter mates. Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma.
Medical subject headings
- Ketotifen
- Skin