The missing link: Mul1 signals mitophagy and muscle wasting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23140636.
- Also identified by DOI 10.1016/j.cmet.2012.10.013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
FoxO3 regulates the transcription of autophagy-related genes that induce mitophagy in muscle wasting. In this issue of Cell Metabolism, Lokireddy et al. (2012) now show that the mitochondrial ubiquitin protein ligase 1 (Mul1) polyubiquitinates the mitochondrial fusion protein Mfn2 and is necessary for FoxO3- and lysosomal-dependent mitophagy in muscle atrophy.