RIPping off GABA release in hypothalamic circuits causes obesity.
basic_science · Level V
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- Record sourced from PubMed, PMID 23140639.
- Also identified by DOI 10.1016/j.cmet.2012.10.014 and PMC identifier 7224334.
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Abstract
Hypothalamic RIP-expressing neurons regulate energy balance, but the precise neural pathways and neurotransmitters mediating this effect remain undetermined. Kong et al. (2012) now demonstrate that RIP neurons regulate energy expenditure and BAT thermogenesis predominantly via a GABAergic arcuate-paraventricular-hindbrain pathway.