Genome-wide association study heterogeneous cohort homogenization via subject weight knock-down.
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- Record sourced from PubMed, PMID 23144770.
- Also identified by DOI 10.1371/journal.pone.0048653 and PMC identifier PMC3277088.
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Abstract
Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if originating from a single well-mixed population. The method was applied to homogenize a Parkinson's disease genome-wide association study cohort.