Molecular dissection of the basal clades in the human Y chromosome phylogenetic tree.
basic_science · Level V
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- Record sourced from PubMed, PMID 23145109.
- Also identified by DOI 10.1371/journal.pone.0049170 and PMC identifier PMC2702739.
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Abstract
One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the revised phylogeny. This analysis made it possible to identify new haplogroups and to resolve a deep trifurcation within haplogroup B2. Our data provide a highly resolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrant of the African continent for the human MSY diversity.