Pharmacokinetics and safety of a phenytoin prodrug given i.v. or i.m. in patients.
case_series · Level IV
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Abstract
ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.
Medical subject headings
- Epilepsy
- Phenytoin
- Prodrugs