Formulations for trans-tympanic antibiotic delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23146430.
- Also identified by DOI 10.1016/j.biomaterials.2012.10.025 and PMC identifier 3511665.
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Abstract
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
Medical subject headings
- Anti-Bacterial Agents
- Ciprofloxacin
- Nanocapsules
- Otitis Media
- Tympanic Membrane