Strategies to reverse endothelial dysfunction in diabetic nephropathy.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23151985.
- Also identified by DOI 10.1038/ki.2012.306 and PMC identifier 3914716.
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Abstract
Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.
Medical subject headings
- Diabetes Mellitus, Experimental
- Diabetic Nephropathies
- Endothelium, Vascular
- Kidney Glomerulus
- Nitric Oxide Synthase Type III