Dynamic microenvironments: the fourth dimension.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23152326.
- Also identified by DOI 10.1126/scitranslmed.3004804.
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Abstract
The extracellular space, or cell microenvironment, choreographs cell behavior through myriad controlled signals, and aberrant cues can result in dysfunction and disease. For functional studies of human cell biology or expansion and delivery of cells for therapeutic purposes, scientists must decipher this intricate map of microenvironment biology and develop ways to mimic these functions in vitro. In this Perspective, we describe technologies for four-dimensional (4D) biology: cell-laden matrices engineered to recapitulate tissue and organ function in 3D space and over time.
Medical subject headings
- Animals
- Biocompatible Materials
- Cell Culture Techniques
- Developmental Biology
- Developmental Biology/methods
- Disease Progression
- Drug Design
- Extracellular Matrix
- Extracellular Matrix/metabolism
- Humans
- Materials Testing
- Tissue Engineering
- Tissue Engineering/methods
- Wound Healing