Autoantibodies, autoimmune disease, and the birth of immune diagnostics.
review · Level V
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- Record sourced from PubMed, PMID 23154275.
- Also identified by DOI 10.1172/JCI66510 and PMC identifier 3484082.
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Abstract
The appearance of autoantibody to DNA followed sequentially by the disappearance of anti-DNA and appearance of DNA antigen in a patient with systemic lupus erythematosus demonstrated that autoantibodies participate in immune complex-mediated pathogenesis. Continuing studies showed that autoantibodies are also useful biomarkers in clinical diagnosis and important reagents for elucidating the structure and function of intracellular proteins in cell biology. Recently, autoantibodies to tumor-associated antigens have been identified in cancer, and these findings have expanded the field of cancer immunodiagnostics.
Medical subject headings
- Antibodies, Antinuclear
- Antigens, Neoplasm
- Immunologic Tests
- Lupus Erythematosus, Systemic
- Neoplasms