Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon.
review · Level V
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- Record sourced from PubMed, PMID 23165262.
- Also identified by DOI 10.1038/nrn3360.
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Abstract
A clear majority of patients with chronic pain are women; however, it has been surprisingly difficult to determine whether this sex bias corresponds to actual sex differences in pain sensitivity. A survey of the currently available epidemiological and laboratory data indicates that the evidence for clinical and experimental sex differences in pain is overwhelming. Various explanations for this phenomenon have been given, ranging from experiential and sociocultural differences in pain experience between men and women to hormonally and genetically driven sex differences in brain neurochemistry.
Medical subject headings
- Brain
- Pain
- Pain Threshold
- Sex Characteristics