Spatially resolved electrochemical sensing of chemical gradients.

Mensack, Meghan M; Wydallis, John B; Lynn, N Scott; Dandy, David S; Henry, Charles S · Lab Chip · 2013

basic_science · Level V

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Abstract

Chemical gradients drive a diverse set of biological processes ranging from nerve transduction to ovulation. At present, the most common method for quantifying chemical gradients is microscopy. Here, a new concept for probing spatial and temporal chemical gradients is reported that uses a multi-layer microfluidic device to measure analyte concentration as a function of lateral position in a microfluidic channel using electrochemistry in a format that is readily adaptable to multi-analyte sensing.

Medical subject headings