Secrets of drug resistance in NSCLC exposed by new molecular definition of EMT.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23172883.
- Also identified by DOI 10.1158/1078-0432.CCR-12-3232 and PMC identifier 3537879.
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Abstract
Non-small cell lung carcinoma (NSCLC) metastasis and drug resistance has been associated with epithelial-to-mesenchymal transition (EMT). This study reports the development of a robust gene expression signature of EMT in NSCLC and reveals new insights into the key molecular events that underlie EMT and drug resistance in NSCLC.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Drug Resistance, Neoplasm
- Epithelial-Mesenchymal Transition
- Lung Neoplasms
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins
- Receptor Protein-Tyrosine Kinases